Monitoring of diazepam treatment: comparison of the results of gas chromatography and radioreceptor methods
Lipska, B.; Webel, L.; Sztaniszlav, D.; Olajos, S.; Beljajeva, R.
Psychiatria Polska 25(6): 6-10
1991
ISSN/ISBN: 0033-2674 PMID: 1841397 Document Number: 373979
26 patients with generalized anxiety disorder have been treated with diazepam (20 mg/24h) for 3 weeks. Blood samples were taken on the days of clinical assessment (before treatment and on the 7th, 14th, 21st day). Determination of drug level was performed parallelly by RRA and GC. The results obtained by both methods agreed well. The intra- and interindividual variations were high. We conclude that diazepam can adequately be measured by both techniques.
Document emailed within 1 workday
Related Documents
Cynober, L.; Ziegler, F.; Coudray-Lucas, C.; Chauffert, M.; Giboudeau, J. 1987: Comparison of methods of assay of amino acids by gas chromatography and ion exchange chromatography Annales de Biologie Clinique 45(5): 537-540Iushchuk, N.D.; Kichik, E.I.; Sergeev, V.V.; Godovannyĭ, B.A.; Tumanov, F.A. 1977: Results of treatment of dysentery patients with streptomycin-dependent vaccine in comparison with other methods of treatment Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 11: 90-94
Derulska, D.; Rokicka-Milewska, R.; Skrobowska-Woźniak, A.; Makowska, K.; Kansy, J. 1981: Comparison of the results of treatment of lymphoblastic leukemia in children by different methods Pediatria Polska 56(9): 985-992
Peat, M.A.; Kopjak, L. 1979: The screening and quantitation of diazepam, flurazepam, chloridazepoxide, and their metabolites in blood and plasma by electron-capture gas chromatography and high pressure liquid chromatography Journal of Forensic Sciences 24(1): 46-54
Ratnayake, W.M.Nimal. 2004: Overview of methods for the determination of trans fatty acids by gas chromatography, silver-ion thin-layer chromatography, silver-ion liquid chromatography, and gas chromatography/mass spectrometry Journal - Association of Official Analytical Chemists 87(2): 523-539
Keown, P.A.; Glenn, J.; Denegri, J.; Maciejewska, U.; Seccombe, D.; Stawecki, M.; Freeman, D.; Stiller, C.; Shackleton, C.; Cameron, E. 1990: Therapeutic monitoring of cyclosporine: impact of a change in standards on 125I-monoclonal RIA performance in comparison with liquid chromatography Clinical Chemistry 36(5): 804-807
Dorman, T. 1983: A multi-centre comparison of prazepam and diazepam in the treatment of anxiety Pharmatherapeutica 3(6): 433-440
Richard, L.; Bugugnani, M.J.; Fouyé, H.; Batten, J. 1985: Valproic acid, a comparison between 2 methods of determination: immunoenzymology and high performance liquid chromatography Annales de Biologie Clinique 43(3): 279-284
Grundy, B.L.; Sanderson, A.C.; Webster, W.W.; Richey, E.T.; Procopio, P.; Karanjia, P.N. 1981: Hemiparesis following carotid endarterectomy: comparison of monitoring methods Anesthesiology 55(4): 462-466
Kanazawa, T.; Sato, Y.; Kawakami, K.; Azuma, Y. 1980: Methods for determination of anticonvulsants in serum. the comparison of enzyme-immunoassay with high-performance liquid chromatography Rinsho Byori. Japanese Journal of Clinical Pathology 28(5): 492-498
Mattioli, S.; Zannoli, R.; Felice, V.; Pilotti, V.; Lazzari, A.; Di Simone, M.P.; Raspadori, A.; Gozzetti, G. 1991: Monitoring esophageal pressure: comparison of various methods and a unique solution Minerva Chirurgica 46(7 Suppl): 11-17
Mayer, W.; Erbe, S.; Wolf, G.; Voigt, R. 1974: The analysis and stability of various 1,4-benzodiazepines of pharmaceutical interest. 2. Ring contraction of nordiazepam and clonazepam. pH-Dependence of hydrolytic cleavage of diazepam(Faustan) and use of kinetic methods for determination of stability behavior of diazepam in solutions of the ampoules Die Pharmazie 29(10-11): 700-707
Klenk, D.C.; Hermanson, G.T.; Krohn, R.I.; Fujimoto, E.K.; Mallia, A.K.; Smith, P.K.; England, J.D.; Wiedmeyer, H.M.; Little, R.R.; Goldstein, D.E. 1982: Determination of glycosylated hemoglobin by affinity chromatography: comparison with colorimetric and ion-exchange methods, and effects of common interferences Clinical Chemistry 28(10): 2088-2094
Roch, O.G.; Blunden, G.; Haig, D.J.; Coker, R.D.; Gay, C. 1995: Determination of aflatoxins in groundnut meal by high-performance liquid chromatography: a comparison of two methods of derivatisation of aflatoxin B1 British Journal of Biomedical Science 52(4): 312-316
Devoe, L.D.; Gardner, P.; Dear, C.; Searle, N. 1989: Monitoring intrauterine pressure during active labor. A prospective comparison of two methods Journal of Reproductive Medicine 34(10): 811-814
Buratti, M.; Pellegrino, O.; Soardo, A.; Colombi, A. 1990: Determination of blood bile acids using high pressure liquid chromatography: comparison of chromatographic, enzymatic and immunoenzymatic methods La Medicina del Lavoro 81(1): 65-74
Baumgart, R.; Cregan, D.; France, M.W.; Drury, M.I. 1981: Home monitoring of diabetes: a comparison of four field methods for analysing glucose levels Irish Medical Journal 74(11): 319-320
Ohtsuka, H.; Shinohara, M.; Kashimura, M.; Yoshida, K.; Okamura, Y. 1988: A comparison of radioreceptor assay and immunocytochemical staining for estrogen receptor in leiomyoma and myometrium Nihon Sanka Fujinka Gakkai Zasshi 40(9): 1400-1404
Nathan, D.M. 1986: New methods for monitoring insulin-dependent diabetes clinical application and results Journal of the Kentucky Medical Association 84(3): 108-112
Miller, W.C.; McCurdy, L. 1984: A double-blind comparison of the efficacy and safety of lorazepam and diazepam in the treatment of the acute alcohol withdrawal syndrome Clinical Therapeutics 6(3): 364-371