Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia
Kastner, P.; Perez, A.; Lutz, Y.; Rochette-Egly, C.; Gaub, M.P.; Chambon, P.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 185(6): 391-401
1991
ISSN/ISBN: 0037-9026 PMID: 1668321 Document Number: 373483
Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions.
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