Effect of sera from acute lymphoblastic leukemia children on proliferation and differentiation of HL-60 promyelocytic leukemia cell line

Swiderska, J.; Szmitkowski, M.; Kondracka, E.

Archivum Immunologiae et Therapiae Experimentalis 38(3-4): 197-201


ISSN/ISBN: 0004-069X
PMID: 2102655
Document Number: 366138
Influence of sera of children with ALL on character (dispersed or compact) and composition (granulocyte or macrophage) of colonies, formed from the human promyelocytic leukemia cell line HL-60, was estimated. An increased activities stimulating formation of dispersed G and M colonies was found in the sera of patients before therapy. Dynamics of colonies formation and their composition in the course of treatment point to some changes in the serum the levels of these activities with a tendency to full normalization in remission.

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