Pharmacokinetics of sodium selenite in human body at different levels of selenium
Guo, J.A.; Wang, X.Y.; Dai, L.M.
Zhongguo Yao Li Xue Bao 12(3): 226-228
1991
ISSN/ISBN: 0253-9756 PMID: 1664167 Document Number: 371722
Twelve healthy adults (6M, 6F) from the endemic area of Keshan disease and Kaschin-Beck's disease and 12 adults from nonaffected area were administered a single oral dose of 4 mg sodium selenite. Selenium in whole blood was determined by fluorescene spectrometry. Their basic levels of blood selenium were 64 .+-. 16 and 220 .+-. 20 ng .cntdot. ml-1, respectively. The concentration-time data were treated by a computer with program 3P87, which revealed 2-compartment models with first order absorption and lag time. The pharmacokinetic parameters of low-Se group were T1/2.alpha. 1.8 .+-. 0.6, h, T1/2.beta. 72 .+-. 18 h, T1/2ka 3.2 .+-. 1.8 h, AUC 3 100 .+-. 500 ng .cntdot. h .cntdot. ml-1, Cl 32 .+-. 7 ml .cntdot. kg-1 .cntdot. h-1 Vc 1.45 .+-. 0.19 L .cntdot. kg-1, Tp 6.1 .+-. 2.0 h, Cp 36 .+-. 4 ng .cntdot. ml-1, AUMC (S1) 130 .+-. 26, VRT 174 .+-. 17 h, MRT 55 .+-. 4 h, and of normal-Se group were T1/2.alpha. 3.4 .+-. 0.7 h, T1/2.beta. 14 .+-. 3 h. T1/2ka 2.3 .+-. 0.6, AUC 1 420 .+-. 210 ng .cntdot. h .cntdot. ml-1, Cl 57 .+-. 7 ml .cntdot. kg-1 .cntdot. h-1, Vc 0.54 .+-. 0.09 L .cntdot. kg-1, Tp 4.6 .+-. 0.9 h, Cp 75 .+-. 5 ng .cntdot. ml-1, AUMC (S1) 25 .+-. 5, VRT 16 .+-. 3 h, MRT 16.1 .+-. 1.5 h.