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Enhancement of susceptibility of sulbactam/cefoperazone-treated bacteria to phagocytes

Tanaka, T.; Iida-Tanaka, K.; Irino, S.

Japanese Journal of Antibiotics 44(7): 732-735

1991

ISSN/ISBN: 0368-2781
PMID: 1886199
Document Number: 370707
Effects of sulbactam/cefoperazone (SBT/CPZ) on the host-parasite relationship were studied using an established mouse macrophage cell line. Since SBT inactivates some types of beta-lactamase strongly, a combination of SBT with CPZ shows marked antibacterial activities against the bacteria producing beta-lactamases. In addition, sub-MIC levels of SBT/CPZ made Escherichia coli more susceptible to bactericidal activity of macrophage. This study provides evidence that SBT/CPZ works in partnership with host defense mechanism against bacterial infections in clinical situations.

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