Autoantibodies directed against lipid membrane components in sera of patients with malignant tumors
Faiderbe, S.; Chagnaud, J.L.; Charrier, M.C.; Peyron, M.A.; Wafflart, J.; Geffard, M.
Cancer Detection and Prevention 15(3): 199-203
1991
ISSN/ISBN: 0361-090X PMID: 2059961 Document Number: 369988
Tumor-associated antigens (Ag) are expressed on neoplastic cells. Using an enzyme-linked immunosorbent assay (ELISA), an attempt was made to evaluate the autoimmune responses directed against lipid membrane components. A comparison was made of autoantibody (autoAb) levels in human sera of 684 patients with malignant tumors and those of 185 controls (healthy subjects and patients suffering from other diseases). A highly significant difference was found between the immunological binding of the groups for only one phospholipids (PL), i.e., phosphatidylinositol (PI). Using ELISA tests and PI-related compounds differing in fatty acid residue types and/or in phosphatidyl group, it was demonstrated that the hydrophilic residue is the immunodominant part recognized by the autoAb detected in sera of cancer patients.