Is Cerebellar Soluble Lectin a major immunological target in multiple sclerosis?
Zanetta, J.P.; Warter, J.M.; Lehmann, S.; Kuchler, S.; Vincendon, G.
Pathologie-Biologie 39(1): 7-11
1991
ISSN/ISBN: 0369-8114 PMID: 2011413 Document Number: 369987
In a recent paper: (Zanetta J.P. et al., Lancet, 1990, 335, 1482-1484) the authors showed that antibodies against the mannose-binding protein Cerebellar Soluble Lectin (CSL) are present in the cerebrospinal fluid of most multiple sclerosis patients. Herein, the properties and roles of the molecule as they are currently understood are described; hypotheses suggested by the consistent presence of anti-CSL antibodies in multiple sclerosis patients are discussed.