The negative effect of enkephalins on kidney energetics in rats with hemorrhages
Slepushkin, V.D.; Grässler, Y.; Scheuch, D.W.
Voprosy Meditsinskoi Khimii 37(2): 51-53
1991
ISSN/ISBN: 0042-8809 PMID: 1654673 Document Number: 369034
Content of adenine nucleotides, lactic and pyruvic acids, glucose and fructose-6-phosphate was studied in kidney of rats with hemorrhage constituting 3% of body mass after intravenous administration at a dose of 100 mg/kg of agonists of mu-opiate receptors DAGO and delta-opiate receptors DADL and dalargin. Stimulation of both these types of receptors amplifies the kidney ischemia developed after hemorrhage, which was expressed as increased decomposition of ATP, decrease in energetic charge of the adenine nucleotide system (DAGO) and increase in content of AMP (DADL, dalargin).