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A new approach to the search for antineoplastic compounds

Nikitina, E.T.; Aĭtkhozhina, N.A.; Esenova, S.S.

Antibiotiki i Khimioterapiia 36(3): 20-24

1991

ISSN/ISBN: 0235-2990
PMID: 1877870
Document Number: 367976
The necessity of using microbial test systems with regular reproduction of associated impairments in cell differentiation and division in screening of antitumor compounds is substantiated. Conditions for induction of such impairments during secondary growth in prokaryotic and eukaryotic mycelial microorganisms were developed. The fungal culture, Fusarium bulbigenum var. blasticola, the growth of whose secondary colonies was selectively inhibited by representatives of various classes of antitumor agents such as alkylating agents, antimetabolites, antibiotics, plant preparations, etc. was isolated.

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