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Experimental approach for the search of effective drug combination in cancer chemotherapy

Bello, J.L.; Kariev, N.I.; Mainardi, J.V.; Betancourt, M.; Lage, A.; Barroso, M.C.; Alfonso, L.

Neoplasma 29(1): 65-71

1982

ISSN/ISBN: 0028-2685
PMID: 7070556
Document Number: 187885
A comparative assay of cytostatic combinations was carried out in a number of transplantable mouse tumors: L1210, Lewis lung carcinoma, Sarcoma 180 and others. The results suggest that the combination cyclophosphamide (CPH) plus procarbazine (PROC) enhances the antitumoral activity in comparison with monochemotherapy. The combination CPH + PROC can be used as basis for the elaboration of more effective polychemotherapy schemes. Combination of CPH + PROC + Prospidine and CPH + PROC + CCNU resulted in enhancement of the treatment effect in experimental tumors.

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