Modification of glybenclamide hypoglycaemia by verapamil in rabbits
Saxena, K.K.; Lata, S.; Saxena, R.S.; Kumar, A.; Srivastava, V.K.
Indian Journal of Physiology and Pharmacology 34(4): 277-278
1990
ISSN/ISBN: 0019-5499 PMID: 2129228 Document Number: 367034
The study was designed to demonstrate the interaction between verapamil and glybenclamide on blood glucose in rabbits. Glybenclamide (0.05 mg/kg, po) induced hypoglycemia was observed 1 h after treatment and persisted till 3 h. Verapamil (8 mg/kg, sc) per se produced hyperglycemia which lasted for 2 1/2 hr. Concurrent administration of verapamil was found to impair significantly the hypoglycemic response of glybenclamide.