HLA-DR RFLP distributions in two groups of aboriginal Australians

Davies, R.; Pace, R.; Jazwinska, E.C.; Serjeantson, S.W.

Australian and New Zealand Journal of Medicine 20(6): 790-793


ISSN/ISBN: 0004-8291
PMID: 1981309
Document Number: 366800
HLA-DR and -DQ typing by restriction fragment length polymorphism (RFLP) in Aboriginal Australians from the Kimberleys and from Coen shows a restricted number of HLA-DR types in these populations. The polymorphism is essentially limited to DR2, DR4, DRw14 and DRw8. The most common DR.DQ RFLP haplotype in Aborigines shows a novel arrangement of DR and DQ alleles that has important implications for histocompatibility matching if the RFLP patterns reflect functional variation in HLA class II molecules.

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