Lipoproteins, elastases and atherogenesis
Hornebeck, W.
Pathologie-Biologie 38(10): 1010-1014
1990
ISSN/ISBN: 0369-8114 PMID: 2290689 Document Number: 365683
Increased lipid deposition and fragmentation of elastic lamellae are main events in atherogenesis. Relationships between lipoproteins and elastase can exist: i) interactions between lipoproteins and arterial wall cells from mesenchymal or inflammatory origin can modulate the expression and secretion of elastase; ii) such neutral proteases can degrade protein constituents of lipoproteins, and modify their physical and biological properties.