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Specificity of elastases: degradation of the oxidized beta-chain of insulin by porcine pancreatic elastase Ii and dog leucocyte elastase

Ardelt, W.; Tomczak, Z.; Dudek-Wojciechowska, G.

Acta Biochimica Polonica 26(3): 267-273

1979

ISSN/ISBN: 0001-527X
PMID: 494946
Document Number: 140377
Porcine elastase II (EC 3.4.21.-), a pancreatic proteinase with elastolytic activity, hydrolyses the oxidized beta-chain of insulin with major cleavages occurring at Leu17-Val18, Phe24-Phe25, Phe25-Tyr26 and Tyr26-Thr27. Canine leucocytic elastase splits the same substrate with major sites at Val12-Glu13 and Val18-Cys19 O3H. This indicates similarity of elastase II to chymotrypsins (EC 3.4.21.1 or 3.4.21.2) and of dog leucocyte enzyme to human granulocyte elastase and porcine pancreatic elastase I (EC 3.4.21.11).

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