Factors of nonspecific resistance in patients with cancer under various types of general anesthesia
Poliakov, S.A.; Alemasova, G.M.
Anesteziologiia i Reanimatologiia 2: 60-63
1990
ISSN/ISBN: 0201-7563 PMID: 2400138 Document Number: 365617
The study of changes in the factors of natural resistance (blood serum bactericidal activity, lysozyme, B-lysines) and immunogenesis (T- and B-lymphocytes, immunoglobulins A, M, G) observed in cancer patients subject to 4 distinct types of anesthesia (ketamine anesthesia, hallothane anesthesia, ester anesthesia, neuroleptanalgesia + N2O) has demonstrated differences in the effect of various anesthesia techniques on the above homeostasis parameters. The changes in natural resistance factors proved to be more informative for predicting the course of the postoperative period. Heterogeneity of changes caused by various types of anesthesia and corresponding clinical and experimental results confirm the effect of anesthesia on the course of the postoperative period. It has been established that ketamine anesthesia affects the T-system (causing its significant inhibition), with ester anesthesia attenuating humoral immunity. Neuroleptanalgesia combined with N2O proved to be the most avequate technique of anesthesia in cancer patients, sparing their body resistance factors. Our results correlate with the data on postoperative complications.