Effects of 5-fluorouracil on cultured rabbit lens epithelial cells
Yamamoto, T.; Soong, H.K.; Lichter, P.R.
Japanese Journal of Ophthalmology 34(3): 325-330
1990
ISSN/ISBN: 0021-5155 PMID: 2079776 Document Number: 365002
The effects of 5-fluorouracil (5-FU) on growth and F-actin structure were investigated in cultured rabbit lens epithelial cells. A dose-inhibition study showed that for its antiproliferative effect on cells, the ID50 of 5-FU is 0.6 mg/l. This is similar to the value reported for subconjunctival fibroblasts and corneal epithelial cells. 5-FU does not affect the F-actin structure of the cells. Although cataract formation by 5-FU has not been reported, susceptibility of the lens epithelial cells to 5-FU should be considered when treating glaucoma patients with this drug.