Pulmonary blastoma. Immunohistochemical characterization of heteromorphic tumor components
Brockmann, M.; Hecker, A.; Müller, K.M.
Pneumologie 44(Suppl 1): 605-606
1990
ISSN/ISBN: 0934-8387 PMID: 2195530 Document Number: 364642
The reaction pattern found in thirteen different pulmonary blastomas was tested with four different polyclonal and six different monoclonal antibodies using the avidin-biotin-reaction. Immunohistochemically, the tumours showed positive reactions, both with antibodies that are considered to be epithelial markers (K11, EMA), and with antibodies that indicate a differening mesenchymal differentiation (vimentine, desmine, protein-S100). It was not possible to label any tumour cells with the antibodies anti-beta-HCG, anti-NSE, anti-lysozyme or anti-CEA. The negative response of the CEA reaction can be useful for the differentiation from pulmonary adenocarcinoma, in particular in the case of tumours with highly differentiated glandular components.