Cryptosin induces backbone structural changes in cardiac Na+ and K+ dependent adenosinetriphosphatase
Venkateswara, R.R.; Dipak, D.; Banning, J.W.; Vaidyanathan, C.S.
Biochemistry International 22(2): 287-294
1990
ISSN/ISBN: 0158-5231 PMID: 1965277 Document Number: 364472
Cryptosin, a new cardenolide, was found to preferentially bind to Na,K-ATPase enzyme (7), which is believed to be the ouabain binding site on cardiac sarcolemmal membrane. CD spectral studies revealed that cryptosin, in the presence of Na+ and Mg++ ions, bind to Na,K-ATPase and induce a dose-dependent change in the backbone structure of cardiac Na,K-ATPase.
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