Group a streptococcal polysaccharide--stimulator of nonspecific cytotoxic reaction in autologous system of spleen cells
Gnezditskaia, E.V.; Bazanova, E.A.; Liampert, I.M.; Beletskaia, L.V.
Biulleten' Eksperimental'noi Biologii i Meditsiny 109(2): 167-169
1990
ISSN/ISBN: 0365-9615 PMID: 2186816 Document Number: 364275
P4 was shown the ability of group A streptococcal polysaccharide (A-PS) to stimulate nonspecific cytotoxic effect of spleen cells on autologous adherent cells (macrophages). The stimulating effect can be observed in vivo under the treatment of spleen cells with A-PS and any antigen (BSA, PPD, M-protein of group A streptococci). In the presence of antigen A-PS can induce nonspecific cytotoxic effect of normal spleen cells (mice CBA, BaLB/c) and of the mice with DHT and therefore these two immunologic phenomena do not depend on each other. Because A-PS has cross-reactive (CR) determinant with thymus epithelial antigen (factor), it can be assumed that via the CR determinant A-PS links with T-cells receptor for this thymus factor and thus realized the stimulating effect as it's functional analogue.