Increase of the number of bone marrow T-suppressor cells under inhibition of immunogenesis during changes of the activity of the neuromediator system
Idova, G.V.; Cheĭdo, M.A.; Al'perina, E.L.
Biulleten' Eksperimental'noi Biologii i Meditsiny 110(9): 287-289
1990
ISSN/ISBN: 0365-9615 PMID: 1980087 Document Number: 363711
Increase of serotoninergic system activity and blockade of dopaminergic system activity led to the change of T- and B-lymphocyte distribution in immunocompetent organs of non-immunized animals. Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP. Role of bone marrow in neuro-immunomodulation is discussed.