Acute leukemia: autologous transplantation of bone marrow cells grown in long-term culture containing low molecular weight natural tumour suppressor
Yang, K.; Teng, A.P.; Pei, Z.T.
Zhonghua Yi Xue Za Zhi 74(5): 287-289; 325-326
1994
ISSN/ISBN: 0376-2491 PMID: 7953919 Document Number: 439147
Fourteen patients with acute myelogenous leukemia and 3 patients with acute lymphoblastic leukemia in complete remission underwent autologous transplantation of their bone marrow cells in long-term culture containing low molecular weight-natural tumour suppressor. Their mean age was 27 years (9-35). Preparative regimen included cyclophosphamide and total body irradiation. All patients received no chemotherapy after transplantation. Follow-up for to 45 months showed that 11 patients remained disease-free survival (DFS) at 15 months, 8 at 24 months, 5 at 30 months, and 1 at 43 months. 5 patients relapsed between 6 and 22 months. One case died from sudden death at 6 months. 3.5-year DFS was 62.7 +/- 15.0%.