Autologous bone marrow transplantation for acute lymphoblastic leukemia
Doney, K.; Buckner, C.D.; Fisher, L.; Petersen, F.B.; Sanders, J.; Appelbaum, F.R.; Anasetti, C.; Badger, C.; Bensinger, W.; Deeg, H.J.
Bone Marrow Transplantation 12(4): 315-321
1993
ISSN/ISBN: 0268-3369 PMID: 8275030 Document Number: 420640
Between December 1979 and February 1991, 89 patients with ALL received autologous BMT. Median patient age was 18.4 years. Ten patients were in first remission, 52 were in second or greater remission and 27 were in relapse at the time of transplant. Conditioning regimens utilized chemotherapy alone (5 patients) or in combination with 10-15.75 Gy total body irradiation (84 patients). Disease-free survival at 1 year is 50% for patients transplanted in first remission, 27% for those in gtoreq second remission and 8% for patients in relapse. Pre- and post-transplant variables were evaluated in univariate and multivariate analyses for their effect on survival and relapse. Factors significantly associated with improved survival were being transplanted in first remission and achieving a self-sustained platelet count gtoreq 20 times 10-9/l in a shorter period of time. A decreased relapse rate after transplant was associated with a lower white blood count at diagnosis, being transplanted in first remission and not being transplanted in relapse.