Studies on the active constituents of Momordica charantia L
Zhu, Z.J.; Zhong, Z.C.; Luo, Z.Y.; Xiao, Z.Y.
Yao Xue Xue Bao 25(12): 898-903
1990
ISSN/ISBN: 0513-4870 PMID: 2104468 Document Number: 363490
Five compounds were isolated from the seeds of Momordica charantia. This paper reports their structure determination by spectral (IR, UV, 1HNMR, 13CNMR, and MS) and chemical methods. The structures of I, II, III, IV and V were elucidated as vicine, mycose, 3-O-(.beta.-D-glucopyranosyl)-24.beta.-ethyl-5.alpha.-cholesta-7, trans-22E, 25 (27)-trien-3.beta.-ol, momorcharaside A and momorcharaside B respectively. Mycose was the first time found in this plant and compound III was the first time found in the genus Momordica. IV and V were new compounds. IV exhibited obvious inhibition of DNA and RNA syntheses in S180 tumor cells in preliminary pharmacological studies.