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Studies of the active constituents of the Chinese drug "duhuo" Angelica pubescents

Li, R.Z.; He, Y.Q.; Chiao, M.; Xu, Y.; Zhang, Q.B.; Meng, J.R.; Gu, Y.; Ge, L.P.

Yao Xue Xue Bao 24(7): 546-551

1989

ISSN/ISBN: 0513-4870
PMID: 2618698
Document Number: 340352
Eight coumarins isolated from the alcohol extract of the Chinese drug "Duhuo", the root of Angelica pubescents Maxim. f. biserrata Shan et Yuan (Umbelliferae) were elucidated to be columbianetin (I), columbianetin acetate (II), columbiadin (III), osthol (IV), isoimperatorin (V), bergapten (VI), xanthotoxin (VII), and columbianetin-.beta.-D-glucopyranoside (VIII), by chemical and spectral analysis. Compound VII was isolated from plant for the first time. All these coumarins were tested on platelet aggregation induced by 2.mu.m ADP. I, II, III, IV, and VII showed strong inhibiting activity against platelet aggregation.

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