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Regulation of the catalytic activity of the monooxygenase enzyme system depending of the substrate structure and phospholipid composition of the model membrane

Kiselev, P.A.; Garda, G.; Finch, S.A.; Stir, A.; Khatyleva, S.Iu.; Akhrem, A.A.

Biokhimiia 55(11): 2058-2071

1990

ISSN/ISBN: 0320-9725
PMID: 2085619
Document Number: 362495
A comparative study of pentoxy- and benzyloxyresorufin dealkylation by a monooxygenase enzyme system in dilauroylphosphatidylcholine micelles and in proteoliposomes was carried out. In proteoliposomes whose lipid matrix is formed by double phospholipid mixtures, a cooperative regulation of the oxidation reaction was found. It was shown that the cooperativity of this process depends on the substrate type as well as on the phospholipid composition of the vesicles and decreases during peroxide oxidation of lipids. The results obtained are discussed in terms of protein-protein and protein-phospholipid interactions in the oligomer ensembles consisting of several cytochrome P-450 LM2 molecules.

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Nametkin, S.N.; Kabanov, A.V.; Evtushenko, G.N.; Chernov, N.N.; Berezov, T.T. 1989: Regulation of the supramolecular structure and the catalytic activity of gamma-glutamyltransferase in the reversed micelle system Bioorganicheskaia Khimiia 15(1): 70-77
Klinov, S.V.; Sugrobova, N.P.; Kurganov, B.I. 1979: Regulation of enzyme activity in adsorptive enzyme systems. II. Influence of dextran sulfate on catalytic properties of lactate dehydrogenase (isozyme M4) Molekuliarnaia Biologiia 13(3): 559-566
Mevkh, A.T.; Sud'ina, G.F.; Lagutina, I.O.; Levashov, A.V. 1985: Catalytic properties of the membrane enzyme prostaglandin H synthetase in a system of inverted micelles of aerosol OT in octane Biokhimiia 50(10): 1719-1723
Lemoine, A.; Williams, D.E.; Cresteil, T.; Leroux, J.P. 1991: Hormonal regulation of microsomal flavin-containing monooxygenase: tissue-dependent expression and substrate specificity Molecular Pharmacology 40(2): 211-217
Alejandre, M.J.; Garcia-Gonzalez, M.; Segovia, J.L. 1988: Correlation between changes in membrane lipid composition induced by dietary lipid and membrane-bound enzyme activity in chick liver Biochemistry International 17(3): 461-469
Gevorkian, E.S.; Tadevosian, I.V.; Iavroian, Z.V.; Gevorkian, G.A. 1986: Effect of hydrocortisone on the phospholipid composition and activity of various enzymes of phospholipid metabolism in the nuclear membranes of the rat liver Biokhimiia 51(10): 1630-1634
Rick, W.; Hockeborn, M. 1982: Determination of the catalytic activity of lipase with trilinolein as substrate Journal of Clinical Chemistry and Clinical Biochemistry 20(10): 745-752
Bakanov, S.A.; Amirov, B.B.; Nurmagambetov, T.Z.; Piotrovskiĭ, S.V.; Kuanysheva, T.K. 1986: Metabolism of the pesticide trichlorometaphos-3 and its effect on the monooxygenase system depending upon the supply of lysine, methionine, threonine and vitamins A, B and C Voprosy Meditsinskoi Khimii 32(4): 98-102
Yamamoto, S.; Kishimoto, K.; Arakawa, T.; Suzuki, H.; Nakamura, M.; Yoshimoto, T.; Takao, T.; Shimonishi, Y.; Tanabe, T. 1997: Arachidonate 12-lipoxygenases. Catalytic properties and regulation of the enzyme gene Advances in Experimental Medicine and Biology 407: 191-196
Shimayama, T.; Sawata, S.; Komiyama, M.; Takagi, Y.; Tanaka, Y.; Wada, A.; Sugimoto, N.; Rossi, J.J.; Nishikawa, F.; Nishikawa, S. 1992: Substitution of non-catalytic stem and loop regions of hammerhead ribozyme with DNA counterparts only increases KM without sacrificing the catalytic step (kcat): a way to improve substrate-specificity Nucleic Acids Symposium Series 27: 17-18
Stresser, D.M.; Blanchard, A.P.; Turner, S.D.; Erve, J.C.; Dandeneau, A.A.; Miller, V.P.; Crespi, C.L. 2000: Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates Drug Metabolism and Disposition: the Biological Fate of Chemicals 28(12): 1440-1448
Vikha, I.V.; Khorlin, A.I. 1973: Role of the carboxyl groups in the substrate and in the inhibitors in the enzyme-substrate and enzyme-inhibitor interaction of hyaluronidases Biokhimiia 38(6): 1237-1242
Makhovskaia, O.V.; Kozlov, S.; Botos, I.; Stepnov, A.A.; Andrianova, A.G.; Gushchina, A.E.; Vlodaver, A.; Mel'nikov, E.E.; Rotanova, T.V. 2007: Forms of LonB protease from Archaeoglobus fulgidus devoid of the transmembrane domain: the contribution of the quaternary structure to the regulation of enzyme proteolytic activity Bioorganicheskaia Khimiia 33(6): 657-660
Sorokoumova, G.M.; Selishcheva, A.A.; Tiurina, O.P.; Alekseeva, S.G.; Martynova, O.M.; Sharf, T.V.; Shvets, V.I. 2002: Effect of water soluble non-membrane proteins on the phospholipid structure Biofizika 47(2): 268-276
Basova, L.V.; Tiktopulo, E.I.; Bychkova, V.E. 2005: Model phospholipid membranes affect the holomyoglobin structure: conformational changes at pH 6.2 Molekuliarnaia Biologiia 39(1): 120-128
Vrielink, A.; Rüger, W.; Driessen, H.P.; Freemont, P.S. 1994: Crystal structure of the DNA modifying enzyme beta-glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose EMBO Journal 13(15): 3413-3422
Sathish, H.A.; Kaul, P.; Prakash, V. 2000: Influence of metal ions on structure and catalytic activity of papain Indian Journal of Biochemistry and Biophysics 37(1): 18-27
Vas, A.; Gachályi, B.; Káldor, A. 1987: Simultaneous microsomal monooxygenase enzyme system induction and inhibition, and the influence of the pharmacogenetic background: potential hazards in multi-drug therapy? International Journal of Clinical Pharmacology Therapy and Toxicology 25(7): 410
Wood, W.G.; Singer, J.; Schmidt, H.-Gayk 2004: Establishment of Reference Intervals for Enzyme Catalytic Activity Concentration Measurements at 37 °C - A Practical Approach Clinical Laboratory 50(7-8): 455-475
Stoeva, E.; Tantcheva, L.; Mileva, M.; Savov, V.; Galabov, A.S.; Braykova, A. 2001: Preventive effect of vitamin E on the processes of free radical lipid peroxidation and monooxygenase enzyme activity in experimental influenza virus infection Advances in Experimental Medicine and Biology 500: 257-260