The polychemotherapy and combined treatment of patients with stage-i and -Ii lymphogranulomatosis and unfavorable prognosis
Demina, E.A.; Kaverzneva, M.M.; Kondrat'eva, N.F.; Agafonov, V.A.
Terapevticheskii Arkhiv 62(7): 72-75
1990
ISSN/ISBN: 0040-3660 PMID: 2251669 Document Number: 361532
As many as 104 patients with lymphogranulomatosis, clinical stages I-II, having an unfavourable prognosis were examined for the efficacy of polychemotherapy and combined treatment. Polychemotherapy was received by 47 patients, combined treatment (chemo- plus radiotherapy) by 57 patients. Complete remissions were attained significantly more often in patients given combined treatment (92%) as compared to patients on polychemotherapy alone (64%). After complete remissions relapses occurred in 60% of the patients on polychemotherapy and in 13% of the patients receiving combined treatment. The 7-year survival without any relapses was significantly higher (85%) in patients on combined therapy as compared to patients given polychemotherapy (36%). However, the 10-year survival appeared the same in both the groups (87 and 88%). Splenectomy affected neither the rate of relapses in both the groups nor the immediate treatment efficacy or survival.