From biopsy to automatic diagnosis
Hochstrasser, D.F.; Funk, M.; Appel, R.D.; Pun, T.; James, R.W.; Hochstrasser, A.C.; Scherrer, J.R.; Pellegrini, C.; Müller, A.F.
Schweizerische Medizinische Wochenschrift 120(49): 1862-1866
1990
ISSN/ISBN: 0036-7672 PMID: 2263927 Document Number: 361156
High resolution two-dimensional gel electrophoresis is a very powerful biochemical tool for analysis of complex protein mixtures. In well defined situations, protein maps, obtained from tissue biopsies or biological fluids by this technique, can be automatically analyzed by computer. Some polypeptide patterns are the fingerprints of diseases. Applying clustering algorithm and learning techniques, the prototype expert system MELANIE recognized patterns and associated the correct diagnosis to the specific pattern.