Dideoxycytidine toxicity on mouse hemopoietic progenitors
Mencoboni, M.; Lerza, R.; Bogliolo, G.; Flego, G.; Gasparini, L.; Pannacciulli, I.
In Vivo 4(3): 171-173
1990
ISSN/ISBN: 0258-851X PMID: 1966801 Document Number: 360204
Several antiviral compounds showed a toxicity or hemopoietic progenitor cells, 2', 3' Dideoxycytidine (ddc) is the most potent drug in vitro against human T cell lymphotropic viruses and is now being tested on patients with AIDS and AIDS-related complex. We studied its toxicity on mouse hemopoietic progenitors. Results reported here show a toxic activity of ddc but further studies are required to ascertain whether this toxicity is of significance during clinical application.
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