Acute renal failure in the allogeneic transplantation of hemopoietic progenitors. the clinical characteristics in a series of 92 patients
Gruss, E.; Tomás, J.F.; Bernis, C.; Rodríguez, F.; Traver, J.A.; Fernández-Rañada, J.M.
Medicina Clinica 111(20): 774-775
1998
ISSN/ISBN: 0025-7753 PMID: 9922967 Document Number: 496898
Analysis of clinical characteristics of acute renal failure (ARF) after allogeneic bone marrow transplantation (BMT). Analysis of 92 patients who developed ARF of 260 patients following BMT. ARF incidence was 35.4%. Sixty three percent of ARF occurred before day 20 after BMT. Duration of ARF was less of 10 days in 72.8%. ARF was non oliguric in the 80.4% of cases. Most common ARF etiologies were: multifactorial (37%), nephrotoxicity (NPH) (33.7%) and veno-occlusive disease of the liver (VOD) (14.1%). ARF secondary to VOD was the most severe: and the longest, where the secondary to NPH was less lever and shorter. Hemodialysis (HD) was necessary in 22.8% of ARF. Mortality in ARF group was 45.6%, higher in HD group (80.9%) than in non-HD group (35.2%) (p < 0.0002). ARF is a frequent complication following BMT. It occurs early, has short duration, is non oliguric, mainly hemodynamic and carries a whose prognosis.