Effects of forced diuresis on butylbutanolnitrosamine induction of bladder tumors in rats
Pliss, G.B.; Frolov, A.G.
Voprosy Onkologii 36(1): 33-36
1990
ISSN/ISBN: 0507-3758 PMID: 2305560 Document Number: 359900
The study was concerned with the effect of forced diuresis on the frequency and morphologic pattern of bladder cancer induced with butylbutanolnitrosamine in rats. An 1.6 times increase in diuresis was followed by inhibition of bladder carcinogenesis, resulting in a 2.5-fold decrease in the tumor rate as compared to controls. The data obtained confirm the earlier suggested hypothesis of "urothelial contact" as well as epidemiologic data.