Toxicological approach to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium rugulosum Thom
Ueno, Y.; Ueno, I.; Sato, N.; Iitoi, Y.; Saito, M.
Japanese Journal of Experimental Medicine 41(3): 177-188
1971
ISSN/ISBN: 0021-5031 PMID: 5314585 Document Number: 35976
The intraperitoneal LD50 of (+) rugulosin was 55 mg/kg to mice and 44 mg/kg to rats. Findings included acute liver injury characterised by centrolobular necrosis and fatty metamorphosis. Subcutaneous administration of the mycotoxin to mice caused an increase of S-GOT activity. (+) Rugolosin was inhibitory to the cellular multiplication of Ehrlich ascites tumour, causing an elongation of the life of tumour-bearing mice. It was also bacteriostatic to Gram+ and Gram- bacteria.