Two cases of advanced gastric cancer with diffuse carcinomatosis of the bone marrow showing a widespread osteoplastic bone metastasis
Kato, M.; Sugano, K.; Saito, E.; Natomi, H.; Takaku, F.; Yaui, H.; Tange, T.; Fukusato, T.; Machinami, R.
Gan no Rinsho. Japan Journal of Cancer Clinics 36(4): 551-556
1990
ISSN/ISBN: 0021-4949 PMID: 2157082 Document Number: 359495
Reported are 2 cases of an advanced gastric cancer with a "diffuse carcinomatosis of the bone marrow" (DCMB) showing a widespread osteoplastic bone metastasis. In a DCBM, a widespread invasion of cancer cells to the bone marrow occurs, causing leukoerythroblastosis, anemia, and disseminated intravascular coagulation. The local reaction in the bone, namely being osteoplastic or osteolytic, has not been discussed in previous papers. Our cases were characterized by an extremely high serum alkaline phosphatase, a "superscan" view of the bone scintigram, and a diffuse osteoplastic bone metastasis with an osteoid increase. Thus we think there are DCBM subtypes with a diffuse osteoplastic bone metastasis.