A case of disseminated carcinomatosis of bone marrow treated by S-1 and cisplatin after distal gastrectomy for early gastric cancer
Tsuji, K.; Doyama, H.; Yamada, S.; Kaneko, Y.; Takemura, K.; Tsuji, S.; Tominaga, K.; Inagaki, S.; Hayashi, T.; Ito, R.; Nakanishi, H.; Kitou, Y.; Takeda, Y.; Yamamoto, M.; Inaki, N.; Yamada, T.; Niwa, H.; Katayanagi, K.; Kurumaya, H.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 39(5): 813-815
2012
ISSN/ISBN: 0385-0684 PMID: 22584338 Document Number: 658663
Patients with bone metastasis originating from gastric cancer experience complications from DIC. They are treated with anticoagulation therapy or platelet transfusion, but their prognosis is poor. Our case was a 50-year-old male who had undergone distal gastrectomy for early gastric cancer[pT1a(M)N0M0, pStage I a]ten years previously. He was admitted to our hospital complaining of backache. As a result of his examination, he was diagnosed with disseminated carcinosis of bone marrow with DIC as a postoperative recurrence of gastric cancer. The patient was treated with combination chemotherapy of S-1 and cisplatin(S-1 80 mg/body, po, day 1-21 and cisplatin 50mg/body, iv, day 8). After one course of treatment, DIC was resolved and his pain was relieved. He survived for about nine months. S-1 and cisplatin are considered to be effective for disseminated carcinosis of bone marrow.