A model of diffusion of anti-cataract drugs into the lens tissue
Chasovnikova, L.V.; Formaziuk, V.E.; Sergienko, V.I.; Vlasimirov, I.A.
Biofizika 35(3): 464-468
1990
ISSN/ISBN: 0006-3029 PMID: 2207189 Document Number: 357621
For modeling anticataract drugs diffusion into the lens surface tension of drugs, their solubility in nonpolar solvent and drug adsorption at air-water and water-lipid monolayer surface were measured. It has been shown that diffusion of many drugs into the lens is limited by their low solubility in a monolayer phase of the membrane. Catachrom concentration in the lens should be the highest, because it can concentrate at interfaces.