Effects of cimetidine, a H2-histamine blocker, on ulcer cicatrization processes in patients with peptic ulcer localized in the duodenal bulb

Belousov, A.S.; Leont'eva, G.V.; Rakitskaia, L.G.; Kolesova, O.E.; Lebkova, N.P.; Akhmad Khzhuzh

Klinicheskaia Meditsina 68(3): 96-99


ISSN/ISBN: 0023-2149
PMID: 2370765
Document Number: 357212
The effect of cimetidine treatment on the level of basal and stimulated hydrochloric acid secretion, on the status of the neurohumoral regulatory apparatus, and on reparative processes in the gastric and duodenal mucosa was studied in patients with peptic ulcers localized in the duodenal bulb. Thirty-six patients were administered 200 mg of cimetidine 3 times during the day and 400 mg at night. Gastric secretion was studied before the use of cimetidine and after 10-14 days of its use. As a result of the study it was concluded that cimetidine treatment does not induce significant suppression of hydrochloric acid secretion in such patients. Cimetidine treatment has an effect on the levels of biogenic amines in the blood and tissues, and accelerates the cicatrization of the ulcer. The optimal period for the establishment of adaptive relationships in the neurohumoral apparatus in response to cimetidine is 10 to 15 days. Longer use of the drug can result in a lowering of adaptation combined with the appearance of erosions.

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