Stimulation of carbohydrate metabolising enzymes by synthetic hypertrehalosemic peptides in thoracic musculature of the American cockroach, Periplaneta americana
Jahagirdar, A.P.; Gole, J.W.; Orr, G.L.; Viswanatha, T.; Downer, R.G.
Archives Internationales de Physiologie et de Biochimie 98(5): 231-235
1990
ISSN/ISBN: 0003-9799 PMID: 1708990 Document Number: 357138
The ability of the synthetic hypertrehalosemic peptides, HT-I and HT-II, to influence the activities of glycogen phosphorylase, trehalase and hexokinase via elevation of Ca++ and cAMP levels was examined in thoracic musculature of the American cockroach, Periplaneta americana. The peptides effect dose- and time-dependent activation of phosphorylase, trehalase and hexokinase activities that occur concomitantly with elevated levels of intracellular calcium. In addition, HT-I increases the accumulation of cyclic AMP in muscle cells.