Erythropoietin: biological aspects and clinical usefulness
Liberato, N.L.; Costa, A.; Barosi, G.
Haematologica 75(4): 346-362
1990
ISSN/ISBN: 0390-6078 PMID: 2276680 Document Number: 356919
In the eighties there has been an enormous increase in our knowledge about erythropoietin, previously defined as "an elusive hormone". In this review we summarize the structural and molecular features, the mechanisms of production and of metabolism, the more important methods of assay, the mechanism of action and the biological effects, the main pathophysiological aspects and the therapeutic usefulness of the hormone.