Benign neurologic accident following anti-rabies vaccination. Unforeseen clinical and biological aspects
Lery, L.; Gaillard, L.; Delphin, D.
Archives Francaises de Pediatrie 32(6): 563-567
1975
ISSN/ISBN: 0003-9764 PMID: 241305 Document Number: 89136
A minor and benign encephalitogenic reactions was observed in the days following administration of suckling mouse brain anti-rabies vaccine. The syndrome appeared at the 18th day of the treatment, undertaken according to Gamet and Atanasiu's shortened treatment schedule. Recovery occured without sequellae after 5 days of corticosteroid therapy. Compared to the reports of the literature, the benignity of the central nervous system involvement was unexpected. Three immunological problems are stressed out: the presence of sheep anti-red blood cells antibodies after antirabies vaccines; the presence of antismooth muscle antibodies; a previous BCG vaccination one month before antirabies treatment might play an adjuvant participation.