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The syndrome of abnormal chromatin clumping in leucocytes: clinical and biological study of a case

Invernizzi, R.; Custodi, P.; de Fazio, P.; Bergamaschi, G.; Fenoglio, C.; Ricevuti, G.; Rosti, V.; Zambelli, L.M.; Ascari, E.

Haematologica 75(6): 532-536

1990

ISSN/ISBN: 0390-6078
PMID: 2098294
Document Number: 356205
The authors report the clinical and biological findings of a case of a rare haematological malignant entity, morphologically characterized by a bizarre nuclear abnormality in granulocyts, consisting of exaggerated chromatin clumping and apparent fragmentation of the nucleus, with a loss of segmentation. They emphasize the coexistence of proliferative and dysplastic characteristics as a distinctive marker of this disorder and suggest it may represent a distinct rare morphological entity among the atypical chronic myeloid leukaemias, Ph1 and bcr negative.

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