The antitumor effect of an extract of human umbilical cord
Mkrtchian, L.N.; Ter-Pogosian, E.R.; Nersesian, A.K.; Petanova, E.V.; Martirosian, S.O.
Voprosy Onkologii 36(8): 956-960
1990
ISSN/ISBN: 0507-3758 PMID: 2219839 Document Number: 355286
The study was concerned with the evaluation of effect of the extract of a human fetal organ, the umbilical cord, on development and growth of such transplantable tumors as Ehrlich's ascites tumor, sarcoma 37, sarcoma 180 and Zajdela's hepatoma as well as of dimethylbenzanthracene- and benzo(a)pyrene-induced cancer. In a subgroup of animals who had been vaccinated once or twice prior to inoculation of cells, a significant inhibition of growth of tumors of all the histologies except sarcoma 180 was observed alongside with a decrease in tumor incidence and partial resorption of ascitic fluid. Preliminary vaccination of rats interfered with dimethylbenzanthracene- and benzo(a)pyrene-induced carcinogenesis reducing tumor incidence and assuring longer latent period and slower progression of cancer.