Cardiogenic shock caused by 5-fluorouracil
Mazet, C.; Dellinger, A.; Vital Durand, D.; Adnaoui, M.; Fournier, G.; Levrat, R.
Annales de Cardiologie et d'Angeiologie 39(3): 179-180
1990
ISSN/ISBN: 0003-3928 PMID: 2344152 Document Number: 354063
The authors report the observation of one patient in whom the first administration of chemotherapy with fluoro-5 uracil has induced a severe but reversible cardiogenic shock. The latter was preceded by a prolonged, constrictive thoracic pain without myocardial infarction constitution. The cardiac toxicity of fluoro-5 uracil has been well described in the form of anginal pains receding with the discontinuation of the treatment. However, the possible occurrence of arrhythmias, of collapse and even sudden deaths leads the authors to suggest the daily clinical and electrical observation of the patients treated with fluoro-5 uractil.