5-Fluorouracil-induced severe but reversible cardiogenic shock: a case report
Akhtar, S.S.; Wani, B.A.; Bano, Z.A.; Salim, K.P.; Handoo, F.A.
Tumori 82(5): 505-507
1996
ISSN/ISBN: 0300-8916 PMID: 9063536 Document Number: 466517
5-fluorouracil cardiotoxicity is increasingly recognized with variable presentation. We report a patient who developed cardiogenic shock due to high-dose 5-fluorouracil infusion (1,000 mg/m-2 every 24 hr for 96 hr). There was no evidence of myocardial necrosis. The patient recovered completely without any residual cardiac dysfunction. The exact cause of 5-fluorouracil toxicity remains to be determined. The case highlights the need for careful monitoring of patients who receive high-dose 5-fluorouracil for the development of cardiotoxicity.