Characterization of RD114-related endogenous cat retroviral elements ECE2
Prösch, S.
Archiv für Experimentelle Veterinarmedizin 44(6): 935-939
1990
ISSN/ISBN: 0003-9055 PMID: 2102652 Document Number: 353143
RD114 virus is an endogenous xenotropic Type C retrovirus of the domestic cat. The genomic DNA of the cat has been shown to contain approximately 20 copies of RD114-related sequences, only one encoding for the replication-competent RD114 virus. An endogenous cat retroviral element ECE2 was isolated by screening a genomic DNA library of cat liver DNA with an env- specific cDNA of RD114 virus. It contained an env region which differed from all RD114-related sequences so far isolated and was homologous to the corresponding region of replication- competent RD114 in respect of the restriction map and partial sequence analysis (p20). However, it was distinguished from this RD114 by a deletion of approximately 1 kbp in the putative pol gene.