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Expression of endogenous retroviral envelope antigen in Ig (+) B cells of immunized 15I5 X 71 chickens

Halpern, M.S.; Mason, W.S.; Ewert, D.L.; Deery, D.T.; England, J.M.

Journal of Immunology 126(3): 1198-1202

1981

ISSN/ISBN: 0022-1767
PMID: 7007501
Document Number: 171608
In a previous study (1), we observed that antigen cross-reactive with structural protein of the endogenous retrovirus RAV-O is expressed in splenic Ig(+) B lymphocytes of immunized 15I5 X 71 chickens. The present experiments were undertaken to determine the relationship of this antigen to viral gag- and env-coded antigenic specificities. As analyzed by immunofluorescence with several antisera, group-specific determinants of the gp85 envelope glycoprotein as well as viral-related type E-specific determinants were detectable in islands of Ig(+) splenocytes; antigenic determinants of viral gag protein were not detected in the splenic islands. These observations indicated that antigen cross-reactive with endogenous retroviral envelope glycoprotein is expressed in Ig(+) B cells.

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