Isolated aspartate aminotransferase elevation due to macroenzyme formation with liver biopsy correlation
Foust, R.T.; O'Brien, J.F.; Schiff, E.R.
American Journal of Gastroenterology 85(1): 88-90
1990
ISSN/ISBN: 0002-9270 PMID: 2296970 Document Number: 352055
Serum aspartate aminotransferase (AST) has rarely been reported to complex with immunoglobulins, resulting in abnormally elevated serum activity. A similar phenomenon occurs with serum amylase, resulting in the more common entity of macroamylasemia. AST macroenzyme formation can occur in the presence or absence of liver disease and, at times, can lead to a false suspicion of liver disease. We describe the abnormal liver histology found in a healthy patient with isolated AST elevation due to AST macroenzyme formation.