Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1
Kaner, R.J.; Baird, A.; Mansukhani, A.; Basilico, C.; Summers, B.D.; Florkiewicz, R.Z.; Hajjar, D.P.
Science 248(4961): 1410-1413
1990
ISSN/ISBN: 0036-8075 PMID: 2162560 Document Number: 350995
Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen responsible for considerable morbidity in the general population. These results presented herein establish the basic fibroblast growth factor (FGF) receptor as a means of entry of HSV-1 into vertebrate cells. Inhibitors of basic FGF prevented HSV-1 uptake. Chinese hamster ovary (CHO) cells that do not express FGF receptors are resistant to HSV-1 entry; however, HSV-1 uptake is dramatically increased in CHO cells transfected with a complementary DNA encoding a basic FGF receptor. The distribution of this integral membrane protein in vivo may explain the tissue and cell tropism of HSV-1.