Methyl vinyl sulphone: a new class of Michael-type genotoxin
Warr, T.J.; Parry, J.M.; Callander, R.D.; Ashby, J.
Mutation Research 245(3): 191-199
1990
ISSN/ISBN: 0027-5107 PMID: 2233840 Document Number: 350737
Methyl vinyl sulphone (MVS) is a labile, Michael-reactive chemical, similar in structure to acrylamide (AA). Given that acrylamide is a reference mammalian mutagen and a rodent carcinogen, studies were undertaken to evaluate the potential genotoxicity of MVS. In common with AA, MVS was non-mutagenic to Salmonella but active as an aneugen to cultured mammalian cells. It is concluded that vinyl sulphones should be regarded as representative of a new class of genotoxic chemical whose mode of action is probably primarily dependent upon Michael reactivity to proteins.