Suppression of T cell proliferation induced by concanavalin a in hemophilia patients
Sasiain, M.C.; de la Barrera, S.; Ruibal Ares, B.; Picchio, G.; Muchinik, G.; Pérez Bianco, R.; de Tezanos Pinto, M.; de Bracco, M.M.
Medicina 50(3): 205-212
1990
ISSN/ISBN: 0025-7680 PMID: 2130206 Document Number: 349868
Concanavalin A (Con-A)-induced suppression of T cell proliferation was studied in 48 patients with severe hemophilia. Two groups of patients were defined according to the proliferative response when increasing numbers of Con A-induced cells were added to a constant number of phytohemagglutinin (PHA)-stimulated autologous T cells: In group A (60%) and in normal controls, higher suppression was achieved when more Con A-induced cells were added; in Group B, increasing numbers of Con A-induced cells produced no suppression of stimulated PHA-triggered proliferation. This effect could be corrected in Group B by inducing suppression in the presence of inhibitors of the oxidative metabolism of arachidonic acid. No correlation was found between the suppression profile and HIV-1 or HBV serology. Clinical evolution, as judged by signs and symptoms of AIDS related complex tended to be better in Group B than in Group A patients. It is suggested that decreased Con A-induced suppression in Group B may represent part of a normal regulatory process that involves products of arachidonic acid oxidative metabolism.