Effect of concanavalin a on lymphocyte interactions involved in the antibody response to type IIi pneumococcal polysaccharide I. Comparison of the suppression induced by con a and low dose paralysis
Markham, R.B.; Stashak, P.W.; Prescott, B.; Amsbaugh, D.F.; Baker, P.J.
Journal of Immunology 118(3): 952-956
1977
ISSN/ISBN: 0022-1767 PMID: 15032 Document Number: 117036
Concanavalin A (Con A) administered at the time of immunization induces suppression of the in vivo splenic plaque-forming cell (PFC) response to type III pneumococcal polysaccharide (SSS-III). As with low dose paralysis of the PFC response to SSS-III, Con A-induced suppression could not be demonstrated in congenitally athymic (nu/nu) mice and could be eliminated partially by treatment with anti-lymphocyte serum (ALS). The kinetics for Con A-induced suppression paralleled those for low dose paralysis of the antibody response to SSS-III. These findings support the view that Con A-induced suppression is produced in vivo by suppressor T cells and that this form of suppression shares with low dose paralysis a common pathway through which suppression is mediated.