The relative dependence of calcium antagonists and neuroleptics binding to brain and heart receptors on drug lipophilicity
Rojratanakiat, W.; Hansch, C.
Journal of Pharmacy and Pharmacology 42(8): 599-600
1990
ISSN/ISBN: 0022-3573 PMID: 1981596 Document Number: 349839
QSAR analysis of the binding of calcium antagonists to brain and heart tissue shows that relative binding to brain tissue increases with increasing octanol/water partition coefficients. A number of antischizophrenic drugs follow the same pattern.
Document emailed within 1 workday
Related Documents
Hulme, E.C.; Birdsall, N.J.; Burgen, A.S.; Mehta, P. 1978: The binding of antagonists to brain muscarinic receptors Molecular Pharmacology 14(5): 737-750Ticku, M.K.; Lee, J.C.; Murk, S.; Mhatre, M.C.; Story, J.L.; Kagan-Hallet, K.; Luther, J.S.; MacCluer, J.W.; Leland, M.M.; Eidelberg, E. 1992: Inhibitory and excitatory amino acid receptors, c-fos expression, and calcium-binding proteins in the brain of baboons (Papio hamadryas) that exhibit 'spontaneous' grand mal epilepsy Epilepsy Research. Suppl 9: 141-149
Radaelli, A.; Caporotondi, A.; Muggia, C.; Pompei, R.; Marchesi, E. 1990: Platelet adrenergic alpha receptors in hypertensive subjects undergoing treatment with calcium antagonists Bollettino della Societa Italiana di Biologia Sperimentale 66(1): 9-13
Feoktistov, I.A.; Baldenkov, G.N.; Barannik, I.V.; Cherviakov, E.B.; Larionov, N.P. 1990: Interaction of calcium agonists and antagonists with Ca-binding proteins and their effect on cyclic nucleotide phosphodiesterase Biokhimiia 55(4): 754-759
Thuillez, C.; Giudicelli, J.F. 1981: Cardiovascular effects of calcium antagonists drug Therapie 36(2): 107-121
Nakagawa, M.; Sawada, S.; Toyoda, T. 1990: Therapeutic drug monitoring of calcium antagonists Nihon Rinsho. Japanese Journal of Clinical Medicine 48 Suppl: 1152-1155
Schoenberger, J.A. 1988: Calcium antagonists: use in hypertension evaluation of calcium antagonists in combination with diuretics Angiology 39(1 Part 2): 87-93
Dzhishambaev, E.D. 1987: Use of calcium antagonists in heart rhythm disorders Kardiologiia 27(5): 109-116
Barbieri, L.; Mestroni, L.; Camerini, F. 1988: Calcium antagonists in congestive heart failure Giornale Italiano di Cardiologia 18(11): 989-996
Gluhovschi, G.H.; Schiller, A.; Barbu, N. 1988: The effect of the association of calcium channel inhibitors with antagonists of H2 histamine receptors on the gastric secretion in duodenal ulcer patients Medecine Interne 26(3): 207-211
Aursnes, I. 2004: Do calcium antagonists prevent heart failure in hypertension? Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin Ny Raekke 124(1): 42-43
Meyer, J. 1983: Use of calcium antagonists in the therapy of coronary heart disease Der Internist 24(7): 408-414
Rafflenbeul, W. 1984: Calcium antagonists in the treatment of coronary heart disease Fortschritte der Medizin 102(27-28): 718-721
Ol'binskaia, L.I.; Vartanova, O.A. 1984: Calcium antagonists in the treatment of ischemic heart disease Kardiologiia 24(2): 10-13
Ochodnický, M.; Ochodnická, E. 1986: Calcium ion antagonists and cerebral resuscitation after heart arrest Casopis Lekaru Ceskych 125(8): 250-251
Zharov, E.I.; Vertkin, A.L.; Prokhorovich, E.A.; Adib, B.M. 1987: Calcium antagonists in the treatment of congestive heart failure Klinicheskaia Meditsina 65(2): 20-27
Pereirinha, A.; Amaro, M.J.; Lopes, M.G.; de Pádua, F. 1993: Calcium antagonists in the treatment of congestive heart failure Revista Portuguesa de Cardiologia: Orgao Oficial da Sociedade Portuguesa de Cardiologia 12(Suppl 4): 47-51; 9
Mack, W.M.; Zimányi, I.; Pessah, I.N. 1992: Discrimination of multiple binding sites for antagonists of the calcium release channel complex of skeletal and cardiac sarcoplasmic reticulum Journal of Pharmacology and Experimental Therapeutics 262(3): 1028-1037
Bleifeld, W.; Spokojny, A. 1983: Therapy of coronary heart disease with calcium antagonists in clinical practice Die Medizinische Welt 34(47): 1335-1339
Levant, B.; Grigoriadis, D.E.; DeSouza, E.B. 1992: Characterization of [3H]quinpirole binding to D2-like dopamine receptors in rat brain Journal of Pharmacology and Experimental Therapeutics 262(3): 929-935